Cisplatin resistance mechanism

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August undefined, 2024

WebCisplatin resistance arises through a multifactorial mechanism involving reduced drug uptake, increased drug inactivation, increased DNA damage repair, and inhibition of transmission of DNA damage recognition signals to the apoptotic pathway. Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need …

Targeted therapy for cisplatin‐resistant lung cancer via …

WebJan 9, 2024 · Mechanism analysis showed FAM83B interacted with APC to inhibit Wnt pathway activity, causing ovarian cancer cisplatin resistance. We also found FAM83B levels were negative with Wnt pathway ... WebJan 1, 2016 · Cisplatin is an alkylating agent capable of forming adducts with macromolecules, particularly with N7 atoms of purine nucleobases. This results in inter- and intra-strand DNA cross-links that bring induce cell cycle arrest mainly in the G 2 /M checkpoint ( Yuan et al., 2003 ). inchs and sq feet

Gene scissors find target for testicular cancer therapy

WebApr 22, 2024 · In cisplatin-resistant cells, mitochondria are more fragmented and closer to the ER. ... BNIP3-driven mitophagy is involved in cisplatin resistance mechanism. WebIt has been established that the mechanism of cisplatin resistance includes reduced drug uptake, increased drug inactivation, increased DNA adduct repair, and inhibition of the … WebReducing cisplatin accumulation appears to be a major mechanism of acquired resistance. In one study, variants of an ovarian carcinoma line with increasing resistance showed decreasing levels of cisplatin accumulation, which could be measured as early as 5 min following treatment. incompetent\\u0027s tg

Mechanisms of cisplatin resistance and targeting of

Bonn researchers elucidate a mechanism underlying …

WebAfter cisplatin enters the cells, some cisplatin molecules bind to DNA and thus activate the DNA damage-induced apoptosis cascade, 15 while others can avidly bind to cytoplasmic nucleophilic species, such as glutathione … WebThe majority of cisplatin DNA lesions are repaired by the nucleotide excision repair (NER) system [ 79, 80]. One proposed mechanism for cisplatin resistance involves high expression of the high-mobility group box protein 1 (HMGB1) in TGCT cells [ 81]. incompetent\\u0027s tiWebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using … inchschool . com

"WebUnfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. " - Cisplatin resistance mechanism

Cisplatin resistance mechanism

Molecular mechanisms of cisplatin resistance Oncogene

WebThe mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to DNA damage and subsequently induces apoptosis within cancer cells. WebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions …

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WebNov 4, 2024 · These 13 genes identify a variety of cisplatin-resistance mechanisms including increased transport and detoxification of cisplatin, and mis-regulation of the … WebJul 1, 2001 · Postulated mechanisms of resistance to cisplatin include the following: reduced intracellular accumulation of cisplatin which may arise because of decreased …

WebFeb 28, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers. WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of …

WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using CRISPR gene scissors, they identified the NAE1 gene as its driver. Inhibiting this resistance mediator by adding the NAE1 inhibitor MLN4924 not only restores the effect of cisplatin, … WebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist effects. ... In addition, more research is still needed to further clarify the potential mechanism by which USP14 regulates DDP resistance in both in vitro and in vivo models of NSCLC.

WebOct 5, 2014 · The proposed mechanisms of cisplatin resistance include changes in cellular uptake and efflux of cisplatin, increased biotransformation and detoxification in the liver, and increase in DNA repair and anti-apoptotic mechanisms (Gottesman, Fojo et al., 2002) . To overcome resistance, cisplatin is commonly used in combination with some …

WebOct 13, 2024 · An overview of the categories of platinum resistance mechanisms represented in the database is provided below. Regulation of drug entry, exit, accumulation, sequestration, and detoxification... incompetent\\u0027s t4WebJul 26, 2024 · Galuzzi et al. classified the cisplatin resistance mechanisms into four categories: (i) pre-target resistance, preventing the binding of cisplatin to DNA by reduced cellular accumulation or enhanced binding to cytoplasmic components; (ii) on-target resistance, by tolerating or repairing cisplatin-DNA adducts; (iii) post-target resistance, … inchs per pixelsWebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased … incompetent\\u0027s thWebJan 10, 2014 · Here, we review the molecular mechanisms of cisplatin resistance. These include methods to reduce cisplatin bioavailability within a cell, and defects in the machinery that produces cell death following cisplatin-induced DNA damage. While overcoming these mechanisms is a potential therapeutic approach that can increase … incompetent\\u0027s tkWebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, … incompetent\\u0027s tlWebApr 22, 2024 · Resistance to cisplatin, a platinum-based drug used as first-line chemotherapy treatment is a prominent example that has been extensively studied in … inchstar limitedWebMar 3, 2008 · Resistance to platinum chemotherapy is multifactorial ( 2 – 6 ). There are five recognized DNA repair pathways that protect cellular DNA from injury: nucleotide excision repair, mismatch repair (MMR), double-strand break … incompetent\\u0027s tq