WebAs a measure of molecular lipophilicity, LogD is among the most important measurements in the drug hunter’s repertoire because it’s our control experiment (Figure 1). Like actin … WebFor example, lipophilic derivatives of drugs are employed in several long acting injectable products to provide sustained drug exposure for hormone replacement therapy and to …
CALCULATION OF DRUG LIPOPHILICITY: THE HYDROPHOBIC By …
WebOct 1, 2004 · Obesity affects the pharmacokinetics of many i.v. anaesthetic drugs. The pharmacokinetics of the new generation of inhalational anaesthetics are affected only slightly by obesity. Ideal body weight is useful when assessing dosage of many (but not all) modern anaesthetic drugs. Recent target-controlled infusion (TCI) models for propofol ... WebLipophilic drugs disproportionately distribute into adipose tissue in obese subjects, ... neonates and infants have larger distribution volumes for water-soluble drugs and smaller volumes for lipophilic drugs. For example, the volume of distribution of gentamicin is 0.5 to 1.2 L/kg in neonates and infants compared with 0.2 to 0.3 L/kg in adults ... office space in knightdale nc
Pharmaceutics Free Full-Text In situ Formation of Polymer ...
WebAug 12, 2024 · Drug developers have traditionally benefited from the ionizability of acidic or basic drugs to form ionic salts that increase water solubility. 1-3 However, this increased water solubility does not always relate to improved oral bioavailability, and therefore specialized technologies are needed to address bioavailability challenges. Lipid-based … WebFeb 7, 2024 · The process was suitable for encapsulating the highly lipophilic drugs cannabidiol and 3-O-acetyl-11-keto-β-boswellic acid and enabled their sustained release with zero order kinetics over up to 10 days. Conclusively, controlled drug release for highly lipophilic compounds within bacterial nanocellulose could be achieved using sustainable ... WebFor example, thiopental is highly lipid soluble, rapidly enters the brain after a single IV injection, and has a marked and rapid anesthetic effect; the effect ends within a few minutes as the drug is redistributed to more slowly perfused fatty tissues. Thiopental is then slowly released from fat storage, maintaining subanesthetic plasma levels. office space in kitchen