Gut microbiota-derived metabolites
WebSep 23, 2024 · The gut microbiota has a crucial effect on regulating the intestinal mucosal immunity and maintaining intestinal homeostasis both in health and in disease state. Many effects are mediated by gut microbiota-derived metabolites and tryptophan, an essential aromatic amino acid, is considered important among many metabolites in the crosstalk … WebMay 3, 2024 · These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. …
Gut microbiota-derived metabolites
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WebNational Center for Biotechnology Information WebIn recent years, the association between gut microbiota derived metabolites and cardiovascular disease has gained wide interest and targeting gut microbiome and metabolic pathway may become a potential therapeutic strategy to prevent and treat cardiovascular disease. Cardiovascular disease is the leading cause of death worldwide …
WebSep 17, 2024 · Aryl hydrocarbon receptor (AhR) can be activated by gut microbiota-derived metabolites, specifically indolic compounds. One of its roles is regulating the expression of the enzymes TDO and IDO1, which catalyse the first and rate-limiting step of the catabolism of the amino acid tryptophan in the kynurenine pathway. WebMay 3, 2024 · These gut microbiota derived metabolites play critical roles in maintaining a healthy cardiovascular function, and if dysregulated, potentially causally linked to CVD. A better understanding of the function and dynamics of gut microbiota derived metabolites holds great promise toward mechanistic predicative CVD biomarker discoveries and …
WebDec 2, 2024 · As gut microbiota regulators, probiotics have a certain therapeutic effect on intestinal inflammation in IBD through restoring the composition of gut microbiota and its derived metabolites [20,21]. In addition, probiotics are famous for their high level of safety, which shows good potential for intestinal diseases, and are expected to provide ... WebFeb 2, 2024 · Cardiovascular diseases (CVD) are major causes of death worldwide. Recently, new roles for intestinal microbiota in pathology and treatment of CVD have been proposed. Butyrate, a bacterial metabolite, is synthesized in the gut and performs most of its functions in there. However, researchers have discovered that butyrate could enter to …
WebDebnath, Kumar, Kumar, Mehta, Yadav (2024) Gut-microbiota derived bioactive metabolites and their functions in host physiology Biotechnol Genet Eng Rev 37(2) 105 …
WebCheolmin Shin, Yong-Ku Kim, in The Complex Interplay Between Gut-Brain, Gut-Liver, and Liver-Brain Axes, 2024. 3.4 Tryptophan metabolism. Gut microbiota can contribute to … inf80006WebGut microbiota-derived metabolites are key hubs connecting the gut microbiome and cancer progression, primarily by remodeling the tumor microenvironment and regulating key signaling pathways in cancer cells and multiple immune cells. The use of microbial metabolites in radiotherapy and chemotherapy mitigates the severe side effects from ... logistic services indiaWebApr 14, 2024 · The gut microbiome is critically involved in maintaining normal physiological function in the host. Recent studies have revealed that alterations in the gut microbiome contribute to the development and progression of cerebrovascular disease via the microbiota-gut-brain axis (MGBA). As a broad communication network in the human … inf 7 bsiinf80014WebThe gut microbiota is a crucial actor that can interact with the host by the production of a diverse reservoir of metabolites, from exogenous dietary substrates or endogenous host compounds. Metabolic disorders are associated with alterations in the composition and … inf789fb1x41WebMar 2, 2024 · Gut-microbiota-derived SCFAs, Trp and BA metabolites have been widely related with intestinal and extra-intestinal disorders such as inflammatory bowel diseases (IBDs), chronic liver diseases, metabolic syndrome, diabetes and cancer [203,204,205,206]. Gut-microbiota-derived metabolites play a key role in inflammatory bowel disease (IBD) . logistic services in hyderabadWebApr 11, 2024 · Disruption of the gut microbiota impairs chemotherapy and/or immune checkpoint blockade treatment across multiple solid tumor malignancies.,,, Outcomes to non-surgical cancer therapies remain heterogeneous and dependent upon baseline immune response, and ongoing work identifies the cancer microbiome as a critical factor shaping … inf806