Hydroxamate-based
WebAdditional hydroxamate moieties, compared to the three in DFO, lead to more stable metal-chelator complexes. (a) The octadentate DFO* extends the chain of DFO by one unit. … WebUS20090247547 - Hydroxamate-based inhibitors of deacetylases B. Publication Number 20090247547 Publication Date 01.10.2009 International Application No. 12411715 International Filing Date 26.03.2009 IPC A61K 31/4162 …
Hydroxamate-based
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WebHydroxamate-based colorimetric method for direct screening of transglutaminase-producing bacteria Microbial transglutaminase (MTGase) is a commercial enzyme that has been applied to many protein containing foods to improve their textural property. Web9 nov. 2024 · Exploring the rich coordination chemistry of Ce, here we report two new entries in the emerging category of hydroxamate-based metal–organic frameworks (MOFs). The two Ce-hydroxamate MOFs exhibited different band structures and photoelectrochemical properties based on their respective coordinative environment
WebSAHA is an effective hydroxamic acid-based inhibitor of HDACs approved by the FDA for the treatment of subcutaneous T-cell lymphoma. This agent has been widely studied both in vitro and in ongoing phase I/II studies in patients with solid tumors and hematological malignancies [22, 24]. Web1 mrt. 2024 · We synthesized a series of aliphatic hydroxamate-based compounds, the WMJ-J compounds, and investigated their anti-HNSCC properties in an effort to develop …
Web21 apr. 2024 · Few tacrine-hydroxamate-based MTDLs were synthesized, and their efficacy was investigated on the AD targets such as ChEs, histone deacetylases (HDACs), Aβ1-42 fibrils and metal ions. Compound 17 was synthesized by reacting intermediate (E)-ethyl3-(4-((3-((6-chloro-1,2,3,4-tetrahydroacridin-9 … Web1 mrt. 2024 · Growing evidence shows that hydroxamate-based compounds exhibit broad-spectrum pharmacological properties including anti-tumor activity. However, the precise mechanisms underlying hydroxamate derivative-induced cancer cell death remain incomplete understood. In this study, we explored the anti-tumor mechanisms of a novel …
Web26 sep. 2024 · Isoxazole is a five-membered heterocycle that is widely used in drug discovery endeavors. Here, we report the design, synthesis, and structural and biological …
Web9 apr. 2024 · New carborane-bearing hydroxamate matrix metalloproteinase (MMP) ligands have been synthesized for boron neutron capture therapy (BNCT) with nanomolar potency against MMP-2, -9 and -13. New analogs are based on MMP inhibitor CGS-23023A, and two previously reported MMP ligands 1 (B1) and 2 (B2) were studied in vitro for BNCT … redme busWeb1 jun. 2024 · The hydroxamate class of compounds is well known for its pharmacological applications, especially in the context of chelation therapy. In this work we investigate the performance of the fungal hydroxamates pyridoxatin (PYR), desferriastechrome (DAC) and desferricoprogen (DCO) as mitigators of stress caused by iron overload (IO) both in … red mech suitWeb1 feb. 2024 · This hydroxamate based ZR resin developed by Triskem has been commonly used to separate Zr from Y targets, but unsurprisingly due to the chemical similarities between the Zr(IV)/Y(III) and Ti(IV)/Sc(III) pair, it also shows high selectivity for Ti and little selectivity for Sc over a range of HCl molarities (Dirks et al., 2015, Radchenko et al ... red medal neon whiteWebThe design template of affinity-based probes targeting metalloproteases consists of a peptidyl hydroxamate zinc-binding group (ZBG), a fluorescent reporter tag, and a … red meat workforce strategyWeb16 mei 2024 · Malachite fines are easily produced in the grinding process, leading to low malachite flotation recovery. Floc-flotation of malachite fines with an octyl hydroxamate and kerosene mixture was studied to improve the flotation recovery, using microflotation, microscopy image observations, contact angle measurements, and Extended … redmed a10 heated air tubeWeb28 jul. 2024 · Abstract In addition to carboxylate and N-donor linkers, hydroxamates are a kind of new emerging ligand to form coordination polymers. However, owing to the difficulty in controlling the reversible formation of strong metal–hydroxamate coordination bonds, … red medallion area rugWebHydroxamate-based peptide inhibitors of matrix metalloprotease 2 Authors Márton Jani 1 , Hedvig Tordai , Mária Trexler , László Bányai , László Patthy Affiliation 1 Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, P.O. Box 7, 1518, Hungary. PMID: 15781326 DOI: 10.1016/j.biochi.2004.09.008 Abstract redmed 5389 airline rd arlington tn 38002