Webb25 juni 2015 · Results: Three heterozygous variants in SMAD3 gene, rs2289263, rs35874463 and rs17228212, were identified. Statistical analyses showed that the … WebbWe identified TGF-beta-responsive genes using genome-wide oligonucleotide microarrays and confirmed their dependency on Smad2, Smad3, or Smad4 by the combination of …
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Webb9 apr. 2024 · This sequence change creates a premature translational stop signal (p.Arg368*) in the SMAD3 gene. It is expected to result in an absent or disrupted protein … Smads (or SMADs) comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development and growth. The abbreviation refers to the homologies to the Caenorhabditis elegans SMA ("small" worm phenotype) and MAD family ("Mothers Against Decapentaplegic") of genes in Drosophila. biography of governor gavin newsom
SMAD3 protein expression summary - The Human Protein Atlas
Webb13 apr. 2024 · The results of the maximal clique centrality algorithm determined that CDK1 is a hub target gene, which can be hinted at by hsa-miR-335, hsa-miR-140, hsa-miR-152, and hsa-miR-195. Because viral proteins boost CDK1 activation for cell mitosis, pharmacological inhibition may have anti-HCV therapeutic promise. WebbAdditionally, the protein expressions of p-Smad3 ( Figure 3 D) and TGF-ß ( Figure 3 E), two indicators of fibrosis, exhibited a similar pattern to apoptosis among the four groups. Figure 3. Protein expressions of apoptosis and fibrosis in LV myocardium by 60 days after the AMI procedure. WebbIn addition, the effects of TGFβ are mediated by the transcription factor Smad3. However, the regulation of Smad3 activity is not well understood. In the present study, quantitative … biography of grandma moses